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Second, we discovered a paradoxical relationship between baseline disease severity and treatment response, wherein patients with more severe disease showed higher rates of improvement

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however, the safety profile of rhGH in children and adults is good Current innovative treatment approaches relate to personalizing conventional rhGH, developing long-acting GH preparations, the prospect of gene therapy, GHGH receptor antagonists and, potentially, new indications Abstract Growth hormone (GH) research and its clinical application for the treatment of growth disorders span more than a century